25 Hydroxy Vitamin D Level, Bone Health, Vitamin D and Calcium Intake in Chilean Patients with Phenylketonuria and Hyperphenylalaninemias

25 Hydroxy Vitamin D Level, Bone Health, Vitamin D and Calcium Intake in Chilean Patients with Phenylketonuria and Hyperphenylalaninemias

Blog Article

Abstract It has been shown that there is a decrease in the concentrations of 25 hydroxyvitamin D (25-OHD) and bone mineral density (BMD) in Rotary Glassware Washers patients with phenylketonuria (PKU) in their follow-up.Our objective was to determine concentrations of 25-OHD in subjects with PKU and hyperphenylalaninemia (HPA).Transversal analytical study considered three groups: G1-PKU with neonatal diagnosis and formula intake without Phe; G2-HPA, without specific treatment and G3-C control group.Sixteen patients per group (aged 6-23) were included.

Levels of 25-OHD, lumbar spine (L2-L4), femur and total BMD, intact parathormone (PTH) and vitamin D (VitD) and calcium intake were calculated.The Kruskal-Wallis statistical test was applied (p-value30 ng/mL).G1-PKU had a higher intake of VitD, with differences among AEG IAE84851FB 80cm Sensefry Maxisense Induction Hob groups.There were no significant differences among groups in relation to BMD and intact PTH.

In conclusion, G1-PKU under treatment and with good adherence, does not present VitD deficiency and no BMD alterations are observed.In contrast, G2-HPA had a lower intake of VitD and decreased 25-OHD concentrations which could affect the bone architecture in the long term.Further studies on the G2-HPA are suggested.